Abstract
Synergy of cancer immunotherapy and radiotherapy.
Highlights
Radiotherapy is a cornerstone of cancer care in nonmetastatic patients
Editorial glioblastoma xenograft model [5], or an inhibitor of PDL1in colon cancer or breast cancer xenografts [3], control of the growth of the radiated tumor and survival of the mice were improved when compared to radiotherapy or the immune checkpoint inhibitors alone
We investigated the influence of PD-1 expression on the systemic antitumor response induced by radiotherapy in melanoma and renal cell carcinoma models
Summary
Radiotherapy is a cornerstone of cancer care in nonmetastatic patients. It has been incorporated into the treatment regimens of major tumor histologies with curative intent, and is broadly applied for almost any tumor type in the metastastic setting to alleviate symptoms. Editorial glioblastoma xenograft model [5], or an inhibitor of PDL1in colon cancer or breast cancer xenografts [3], control of the growth of the radiated tumor and survival of the mice were improved when compared to radiotherapy or the immune checkpoint inhibitors alone. In a separate study where mice received a CTLA-4 inhibitor and radiotherapy, PD-L1 was one of the most upregulated genes in resistant tumors, and addition of a PD-L1 inhibitor significantly improved responses of resistant tumors [6].
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