Abstract
Definitions of synergy in drug combinations must be based on a comparison with a non-interactive ‘null’ model. Many such definitions have been proposed. One popular definition is based on linearity of the isoboles—the iso-effective contours of the combination. Unfortunately, linear contours only correspond to a null model in the special case that the dose-response curves of the constituent components are similar (the same up to rescaling transformation). An alternative and general null model is proposed and some examples are given of the isoboles arising from it.
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