Abstract
MamC-mediated biomimetic magnetic nanoparticles (BMNPs) have emerged as one of the most promising nanomaterials due to their magnetic features (superparamagnetic character and large magnetic moment per particle), their novel surface properties determined by MamC, their biocompatibility and their ability as magnetic hyperthermia agents. However, the current clinical application of magnetic hyperthermia is limited due to the fact that, in order to be able to reach an effective temperature at the target site, relatively high nanoparticle concentration, as well as high magnetic field strength and/or AC frequency are needed. In the present study, the potential of BMNPs to increase the temperature upon irradiation of a laser beam in the near infrared, at a wavelength at which tissues become partially transparent, is explored. Moreover, our results also demonstrate the synergy between photothermia and chemotherapy in terms of drug release and cytotoxicity, by using BMNPs functionalized with doxorubicin, and the effectiveness of this combination therapy against tumor cells in in vitro experiments. Therefore, the findings of the present study open the possibility of a novel, alternative approach to fight localized tumors.
Highlights
Nanomedicine has emerged in recent decades as the alternative to solve the limitations of current therapeutic tools in the treatment of localized diseases, especially cancer
Thepresent resultsstudy from the present study offer a potential therapy able to efficiently cause cell death based on temperature increases at low biomimetic magnetic nanoparticles (BMNPs) doses
Photothermal therapy has emerged as a good alternative to solve the limitations of offer a potential therapy able to efficiently cause cell death based on temperature increases at low BMNP doses
Summary
Nanomedicine has emerged in recent decades as the alternative to solve the limitations of current therapeutic tools in the treatment of localized diseases, especially cancer. Several smart nanomaterials have been developed with the goal of using them both as nanocarriers for a targeted chemotherapy, and as agents able to exert a physical effect on the target tissues [1,2]. In this context, one of the most widely studied physical effects is magnetic hyperthermia, or local heating induced by the application of alternating magnetic fields. Magnetic hyperthermia results in the production of localized heat with temperatures raising up to 42–46 ◦ C at the tumor site, which is able to kill cancer cells through apoptosis or necrosis [3,4,5]. The current clinical application of magnetic hyperthermia is still under development [12], somehow limited due to the need of a relatively high
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