Abstract
Mixed-species biofilms are involved in a wide variety of infections. We studied the synergistic interactions during dual-species biofilm formation among isolates of Pseudomonas aeruginosa, Acinetobacter baumannii, and Stenotrophomonas maltophilia. Isolates were cultured as single-species and all possible combinations of dual-species biofilms. The 61 A. baumannii biofilms increased by 26-fold when cultured with S. maltophilia isolates; 62 A. baumannii biofilms increased by 20-fold when cultured with S. maltophilia isolates; and 31 P. aeruginosa biofilms increased by 102-fold when cultured with S. maltophilia 106. Synergy was observed between two isolates, including those that inherently lacked biofilm formation ability.
Highlights
Mixed-species biofilms are involved in a wide variety of infections
The aim of this study was to evaluate the occurrence of synergistic interactions during dual-species biofilm formation by the bacteria isolated from respiratory tract of these patients
With 18 combinations, biofilm formation by two species was significantly greater than biofilm production by any of the single species
Summary
Mixed-species biofilms are involved in a wide variety of infections. We studied the synergistic interactions during dual-species biofilm formation among isolates of Pseudomonas aeruginosa, Acinetobacter baumannii, and Stenotrophomonas maltophilia. Bacterial species isolated from cases with respiratory tract infections usually show strong resistance to antimicrobial agents; this could be related to the potential for biofilm formation in respiratory tract. The aim of this study was to evaluate the occurrence of synergistic interactions during dual-species biofilm formation by the bacteria isolated from respiratory tract of these patients.
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