Abstract
Purpose: To determine the nutraceutical effect of mixtures containing Lactobacillus nagelii/betanin on the carbohydrate and lipid metabolism of mice.Methods: Lactobacillus nagelii and betanin were isolated from the raw materials. These components were subsequently assessed for their anti-hyperglycemic and hypolipidemic activities, and administered individually or combined in normoglycemic and diabetic mice. These animals were subjected to a standard OGTT and given an atherogenic diet.Results: The combination of L. nagelii (2.0 × 109 CFU/mL) and betanin (30 mg/kg body weight) exerted a significant (p < 0.01) and prolonged reduction of postprandial blood glucose (30 - 120 min). Interestingly, a mixture of L. nagelii (1 ×107 CFU/mouse/day) with betanin (10 mg/kg body weight) administered for 30 days, produced favourable effects (p < 0.01) in the lipid profile of mice previously treated with an atherogenic diet. These mixtures significantly ameliorated (p < 0.01) hypoinsulinemia, hyperleptinemia and increased the levels of adiponectin.Conclusion: The simultaneous administration of L. nagelii and betanin in mice produced a beneficial change in blood glucose and lipids in mice, indicating a synergistic nutraceutical effect. However, there is a need to develop this therapy further for potential application in humans
 Keywords: Lactobacillus nagelii, Betanin, Anti-hyperglycemic, Hypolipidemic
Highlights
Traditional beverages and colored berries have been used as natural sources to treat diverse illnesses [1]
The simultaneous administration of L. nagelii and betanin in mice produced a beneficial change in blood glucose and lipids in mice, indicating a synergistic nutraceutical effect
The aim of this study was to determine the effect of L. nagelii, isolated from the medicinal “coyol wine”, and betanin isolated from the medicinal plant Phytolacca thyrsiflora, on blood glucose and lipid profile of mice
Summary
Traditional beverages and colored berries have been used as natural sources to treat diverse illnesses [1]. Betalains are considered as nutraceuticals due to their capacity to improve lipid profile in humans [7,8] Some medicinal plants such as those of the Phytolacca genus are used as traditional medicines and their berries are frequently consumed to treat diverse health problems including type 2 diabetes mellitus (DM2) [7,8,9]. The berries of these plants accumulate high amounts of betalains with antioxidant activity. The leaves and berries of some plants belonging to the Phytolacca genus have been tested in murine models in order to explore their anti-obesity activities [9]
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