Abstract
Three kinds of magnetic nanoparticle, tetraheptylammonium capped nanoparticles ofFe3O4,Fe2O3 and Ni have been synthesized, and the synergistic effect of these nanoparticles onthe drug accumulation of the anticancer drug daunorubicin in leukaemia cellshas been explored. Our observations indicate that the enhancement effect ofFe3O4 nanoparticles is muchstronger than that of Fe2O3 and Ni nanoparticles, suggesting that nanoparticle surface chemistry and size as well asthe unique properties of the magnetic nanoparticles themselves may contributeto the synergistic enhanced effect of the drug uptake of targeted cancer cells.
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