Abstract
Salicylic acid (SA) has been frequently used as a facial chemical peeling agent (FCPA) in various cosmetics for facial rejuvenation and dermatological treatments in the clinic. However, there is a tradeoff between therapeutic effectiveness and possible adverse effects caused by this agent for cosmetologists. To optimize the cosmetic efficacy with minimal concentration, we proposed a chemical permeation enhancer (CPE) azone to synergistically work with SA on human skin in vivo. The optical properties of human skin after being treated with SA alone and SA combined with azone (SA@azone) were successively investigated by diffuse reflectance spectroscopy (DRS) and optical coherence tomography (OCT). Our results revealed that as the SA concentration increased, the light reflectance decreased and the absorption increased. We also found that SA@azone exhibited a synergistic effect on enhancing light penetration and OCT imaging depth. We demonstrated that the combination of DRS and OCT techniques could be used as a noninvasive, rapid and accurate measurement method to monitor the subtle changes of skin tissue after treatment with FCPA and CPE. The approach will greatly benefit the development of clinical cosmetic surgery, dermatosis diagnosis and therapeutic effect inspection in related biomedical studies.
Highlights
Rejuvenation and usually require repeated dose[16]
We explored the synergistic effect of Salicylic acid (SA) combined with azone (SA@azone) with diffuse reflectance spectroscopy (DRS) and Optical coherence tomography (OCT)
Dynamic alterations of spectra features and images of human skin before and after being applied with SA and SA@azone at different time intervals were investigated by DRS and OCT
Summary
Rejuvenation and usually require repeated dose[16]. to optimize the efficacy of SA with minimal dose is of vital significance in clinical facial applications. FCPAs can effectively cause the morphological structure and optical property variations of skin tissue. Optical spectrometry has been employed as a non-invasive, simple, and fast method for biomedical study of dermatoses[19]. As a result, combining high-sensitivity detection of spectrometry with obvious morphologic visualization of OCT can potentially provide comprehensive information of biological tissues. The cooperation of these two techniques will allow for disease diagnosis as well as real-time treatment monitoring, and improve disease management with reduced risks for the patients. Morphologic imaging and optical properties of skin tissue demonstrated that the SA@azone could maximize the chemical facial rejuvenation with minimum risks
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