Abstract
Purpose : To study the effects of a combination of Yiqi Huazhuo Gushen formula and valsartan on metabolic syndrome (MetS) complicated with microalbuminuria. Methods : Patients with MetS (100), recruited from Department of the Traditional Chinese Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Department of Integrated Traditional Chinese and Western Medicine, Huashan Hospital, Fudan University; and Department of Endocrinology, Hospital of Integrated Traditional Chinese and Western Medicine in Yueyang, Shanghai University of Traditional Chinese Medicine, were randomly divided into two sets: control group (n = 50) given valsartan treatment, and Chinese herbal medicine (CHF) group (n = 50) given Yiqi Huazhuo Gushen formula in addition to valsartan. Both therapeutic regimens were given once a day for 12 weeks. The parameters measured were conversion rate of microalbuminuria (MA), ratio of urinary albumin to creatinine (UACR), 24- h total volume of urinary protein (24hTP), urinary transferrin, urinary β2 microglobulin, constitutional index (CI), and waist-hip ratio (WHR). Other indices assessed were peak systolic and diastolic pressure (SBP and DBP), mean arterial blood pressure (MABP), fasting plasma glucose (FPG), postprandial 2 h blood glucose (2hPG), glycosylated hemoglobin (GH), steadystate model for insulin resistance (HOMA-IR), total cholesterol (TC), glycerin trilaurate (TG), low density lipoprotein (LDL), and high-density lipoprotein (HDL). Results : All 100 subjects completed the clinical study. The outcome revealed that compared with 10.00 % in controls, the negative conversion of MA reached 28.00 % in the CHF group (p < 0.050). CHF produced reductions in MA, UACR, BMI, 24hTP and urinary β2 microglobulin (p < 0.05). It also led to marked increases in BMI, WHR, SBP, MAP, FPG, 2hPPG, HbA1c and HOMA-IR, and significant decreases in TG (p < 0.05). Conclusion : These results suggest that CHF treatment results in alleviation of microalbuminuria and multiple cardiovascular risk factors in metabolic syndrome complicated with microalbuminuria. These effects correlate with improvements in insulin sensitivity and rectification of abnormal fat distribution. Keywords : Metabolic syndrome, Microalbuminuria, Yiqi Huazhuo Gushen formula, Insulin resistance, Central obesity
Highlights
Diagnostic criteriaMicroalbuminuria (MAU) is an important disorder in metabolic syndrome (MetS), and a serious risk factor for angiocardiopathy [1]
Following treatment with anti-hypertensive, hypoglycemic, lipid-lowering drugs, some patients still remain MAU-positive, and the progression of renal disorder cannot be effectively controlled. This is associated with the fact that the renal damage in MetS patients is caused by a variety of risk factors which further aggravate MAU and impair kidney function [2]
Patients with MetS complicated with MAU who were recruited from Department of the Traditional Chinese Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Department of Integrated Traditional Chinese and Western Medicine, Huashan Hospital, Fudan University and Department of Endocrine; and Hospital of Integrated Traditional Chinese and Western Medicine in Yueyang, Shanghai University of Traditional Chinese Medicine, were randomly divided into two sets: control set (n = 50) given valsartan treatment, and Chinese herbal medicine (CHF) group (n = 50) given Yiqi Huazhuo Gushen formula in addition to valsartan
Summary
Microalbuminuria (MAU) is an important disorder in MetS, and a serious risk factor for angiocardiopathy [1]. Following treatment with anti-hypertensive, hypoglycemic, lipid-lowering drugs, some patients still remain MAU-positive, and the progression of renal disorder cannot be effectively controlled. This is associated with the fact that the renal damage in MetS patients is caused by a variety of risk factors which further aggravate MAU and impair kidney function [2]. In the treatment of MetS MAU, comprehensive control and intervention for various risk factors must be strengthened so as to improve therapeutic effectiveness. Treatment should use drugs for replenishing kidney qi and clearing collaterals based on Yiqi Huaju formula which is incorporated into Yiqi Huazhuo Gusheni formula [5]
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