Abstract
There were no significant differences between the activities of RH-5849, tebufenozide, and halofenozide on 4th instars of Aedes aegypti (L.). Methoxyfenozide was almost 10 times more active (LC50 = 0.22 mg kg-1) than the other ecdysteroid agonists. Halofenozide, methoxyfenozide, tebufenozide, and RH-5849 caused premature wing disk evagination and also caused the larval thorax to bloat on the dorsoventral sides resulting in a larval-pupal intermediate thorax. Methoxyfenozide induced these effects in the lowest concentration. Further molting disturbances (e.g., hanging larval exuvium, head capsule slippage failure) and a more intense sclerotization and melanization of the thorax also were noted. Although verbutin did not show significant effects with any of the tested ecdysteroid agonists under actual test conditions, some improvements could be found in the use of RH-5849 and tebufenozide.
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