Abstract
Human fibroids are highly prevalent uterine tumors composed of proliferating transformed myometrial cells and excessive disordered extracellular matrix (ECM). The gonadal hormone progesterone is known to induce and maintain leiomyoma growth. Simvastatin, primarily used to treat hyperlipidemia, was recently shown to have anti-proliferative and pro-apoptotic effect on leiomyoma cells and xenograft model. Moreover, simvastatin is thought to modulate progesterone levels. Our objectives are to examine effect of simvastatin on ECM production and leiomyoma stem cells, and evaluate the combined effect of simvastatin and ulipristal acetate (UPA), a progesterone receptor modulator.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
