Abstract
ObjectivesRecent studies have associated neck circumference (NC) with insulin resistance (IR). We examined whether such relation was modified by other metabolic risk factors.MethodsThe study samples were from a community-based health examination survey in central China. A total of 2588 apparently healthy Chinese men and women were included.ResultsPlasma levels of total cholesterol (TC), HDL-C, uric acid (UA) and diastolic blood pressure (DBP) were independently associated with NC after adjusted for age, sex, body mass index (BMI), waist circumference (WC) and hip circumference (HC) (P = 0.009, 0.001, 0.015 and 0.015, respectively). We observed significant interactions of NC with triglyceride (TG) and UA (all the p for interaction = 0.001) in relation to HOMA-IR. It appeared that the associations between NC and HOMA-IR were more evident in those with higher UA or TG level.ConclusionsOur data indicate that in apparently healthy Chinese adults, there were synergistic effects of UA, TG and neck circumference on insulin resistance.
Highlights
Neck circumference is a proxy for upper-body fat and a reliable, simple, time saving screening measure, among numerous others such as body mass index (BMI) and waist circumference (WC), for identification of individuals with excess body fat or its abnormal distribution
The characteristics of the study participants by neck circumference In total 2588 apparently healthy Chinese adults were included in the present study
neck circumference (NC) was positively related to BMI, WC, hip circumference (HC), and Waist/hip ratio (WHR)
Summary
Neck circumference is a proxy for upper-body fat and a reliable, simple, time saving screening measure, among numerous others such as BMI and WC, for identification of individuals with excess body fat or its abnormal distribution. NC has been related to various metabolic risk factors such as blood pressure and lipids [3,4], independent of overall adiposity (body mass index) and central obesity (waist circumference or visceral adipose tissue) [1]. It remains unclear whether these risk factors modify the relation between NC and IR [5]. We comprehensively analyzed the associations of NC and other metabolic risk factors, and their interactions in relation to insulin resistance in a large cohort of apparently healthy Chinese adults
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