Abstract
Background Cisplatin and its derivatives are important drugs in cancer therapy. It has been widely used for its potent cytotoxic effects upon a variety of tumors types including cervical carcinoma. However, the administration of cisplatin is associated with serious side effects, including nephrotoxic and neurotoxic events. There have been several studies aimed at finding drugs able to potentiate the antiproliferative effects of cisplatin without increasing the already serious side effects, but the search has not been successful.
Highlights
Cisplatin and its derivatives are important drugs in cancer therapy
Synergistic effects of mifepristone on the cytotoxicity of cisplatin in cervical carcinoma cell lines and tumors grown in athymic mice
In this work we investigated the ability of a progesterone antagonist, mifepristone, to modulate the cytotoxic effects of cisplatin in cancer cell lines and in a model of cervix cancer in athymic mice
Summary
Cisplatin and its derivatives are important drugs in cancer therapy. It has been widely used for its potent cytotoxic effects upon a variety of tumors types including cervical carcinoma. Synergistic effects of mifepristone on the cytotoxicity of cisplatin in cervical carcinoma cell lines and tumors grown in athymic mice Rafael Jurado*, Angélica López-Flores, Aarón Álvarez-Figueroa and Patricia García-López Address: Subdirección de Investigación Básica, Instituto Nacional de Cancerología
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