Abstract
INTRODUCTION. Actinomycin D (AD) is a common DNA-damaging agent. We have recently reported that AD-induced apoptosis in human megakaryoblastic leukemia cell line CMK-7 was greatly accelerated by concomitantly added colcemid (CL), a cytoskeletondamaging agent (1). The present work was conducted to investigate the synergistic enhancement of apoptosis by the combination of three different DNA-damaging agents AD, etoposide (VP-16) and mitomycin C (MMC) with cytoskeleton-damaging agents colcemid (CL), cytochalasin D (CD) and vinblastin (Vin) in different human tumor cell lines.
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