Abstract
Despite the numerous studies on dendrimers for biomedical applications, the antibacterial activity of anionic phosphorus dendrimers has not been explored. In our research, we evaluated the antibacterial activity of modified polycationic and polyanionic dendrimers in combination with levofloxacin (LVFX) against Gram-negative (Escherichia coli ATCC 25922, Proteus hauseri ATCC 15442) and Gram-positive (Staphylococcus aureus ATCC 6538) bacteria. In the case of Gram-negative bacteria, we concluded that a combination of dendrimers and antibiotic gave satisfactory results due to a synergistic effect. The use of fluoroquinolone antibiotics, such as LVFX, not only caused resistance in disease-causing microorganisms but also increased environmental pollution. Therefore, reduction of drug dosage is of general interest.
Highlights
Antimicrobial resistance is an increasing global problem
We estimated the combined action of PPI glycodendrimer PPI-G3-DS-Mal and LVFX against the common human pathogens, E. coli, P. hauseri, and S. aureus
For the first time, we report that the PPI glycodendrimer PPI-G3-DS-Mal (Figure 2) has the potential to enhance antibacterial activity against Gram-negative bacteria when combined with FQ antimicrobials
Summary
Antimicrobial drugs, antibiotics, often cause bacterial resistance. This is responsible for many therapy failures. Dendrimers are soft hyperbranched nanoparticles whose size, topology, and flexibility can be rigorously controlled during their synthesis. They are generally prepared via the reiteration of a sequence of reactions starting from a core molecule to introduce repeating branching units. This allows for the grafting of a variety of functional groups on their outer shell which can interact with other (macro) molecules [1,2,3,4]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
