Synergistic effects in the processes of protein multicomponent sorption

Abstract

Investigations of sequential and simultaneous sorption of protein pairs on cation exchangers demonstrated a number of synergistic effects. The synergism of protein sorption is determined by multipoint binding of protein macromolecules with the sorbent surface and by the possibility of multilayer packing of proteins in the sorbent phase. It was shown that selectivity of multicomponent protein sorption changes during the process. This effect influences protein desorption dynamics. The band front of the elution peak is enriched with the protein component which was selectively sorbed in the final stage of the sorption process.