Synergistic effect of poly(acrylamide)-incorporated poly(L-ascorbic acid) hydrogels in controlled release and wound dressings

Abstract

In this study, hydrogel specimens were synthesized by acrylamide (AAm) implying different quantities of L-ascorbic acid (LAA) vis-à-vis γ-rays radiation technique. The prepared gels were characterized by various techniques. Fix’s theory was applied to poly(acrylamide) (P(AAm)/LAA) hydrogels and diffusion coefficients were evaluated. Hardness, water vapor transmission rate, tensile strength, and degree of adhesiveness were preformed on gel systems. The outcome results indicate that the hydrogel specimens are conveniently utilized in wound dressings as the first application. The second application of this gel system is drug release of anti-fungal terbinafine hydrochloride (TER-HCl), which was used in skin wound healings. Adsorption and release of TER-HCl to and fro from P(AAm/LAA) hydrogel specimens were examined. The impact of PLAA quantities into the gelling specimens on the adsorption capacities and the impact of pH on the releasing behavior of TER-HCl were investigated. The results showed the TER-HCl adsorption capacities of hydrogels are found to rise up from 9.5 ± 0.22 to 99 ± 0.18 mg TER-HCl per g dry gel, dependent on the gradient increment in quantity of PLAA in the gel structures. The results of in vitro TER-HCl release in different buffer solutions revealed that the paramount parameters affecting the drug release behavior of gel systems are pH of surrounding media and quantity of PLAA inside. In sum up, the prepared hydrogels have synergistic effect and they may be utilized in wound dressing and TER-HCl drug release of skin wound healings applications as well.