Abstract
In recent years, there has been an increase in the production of several types of nanoparticles (Nps) for different purposes. Several studies have been performed to analyse the toxicity induced by some of these individual Nps, but data are scarce on the potential hazards or beneficial effects induced by a range of nanomaterials in the same environment. The purpose of the study described here was to evaluate the toxicological effects induced by in vitro exposure of human cells to ZnO Nps in combination with different concentrations of other metal oxide Nps (Al2O3, CeO2, TiO2 and Y2O3). The results indicate that the presence of these Nps has synergistic or antagonistic effects on the cell death induced by ZnO Nps, with a quite marked beneficial effect observed when high concentrations of Nps were tested. Moreover, analysis by Western blot of the main components of the intracellular activation routes (MAPKs and NFκB) again showed that the presence of other Nps can affect cell activation. In conclusion, the presence of several Nps in the same environment modifies the functional activity of one individual Np. Further studies are required in order to elucidate the effects induced by combinations of nanomaterials.
Highlights
The unusual properties of nanoparticles (Nps) are on the basis of their great expansion due to their potential applications in different areas
The combination of different concentrations of Al2O3 Nps with 60 μg/mL zinc oxide (ZnO) Nps led to an increase in the viability of the Jurkat cells compared to ZnO Nps alone
Al2O3 Nps seem to have a protective effect on cells when they are in contact with ZnO Nps
Summary
The unusual properties of nanoparticles (Nps) are on the basis of their great expansion due to their potential applications in different areas (energy, food, health, clothing, cars, etc.) This situation has led to an increase in the release of different nanomaterials into the environment and their potential effects on the ecosystem and human health are becoming a major concern [1]. Zinc oxide (ZnO) and titanium oxide (TiO2) Nps are used in the production of sunscreens and cosmetics due to their capacity to block both UV-A and UV-B rays [2]. This is a potentially important source of Np contamination due to wash-off from individuals into the environment, which can contaminate water and soil. Y2O3 Nps are widely used for various rare earth-doped materials and they play an important role in potential applications in biological imaging and photodynamic therapy [9,10]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
