Abstract
Commonly consumed fruit juices possess low inhibitory activity of angiotensin I-converting enzyme (ACE), which plays central role in elevation of blood pressure. The ACE inhibitory activity of fruit–seed mixed juice may be improved via synergistic interactions. In this study, the investigated synergistic, additive, and antagonistic effects of fruit–seed combination on ACE inhibition were investigated. Thirteen fruits and 15 seeds including legumes, nuts, and cereals were combined in pairs; pear-hemp seed-pumpkin seed juice (3-mixed juice) displayed the highest ACE inhibition resulting from synergistic interactions. Additionally, nitric oxide production in human endothelial cells was promoted by 3-mixed juice. Three-mixed juice showed antioxidant activities such as DNA protective, DPPH radical scavenging, and reducing effects. These results suggested that combinations of different food categories are beneficial for improving biological functions such as vascular health. Three-mixed juice, which shows high ACE inhibitory activity, may be useful as an anti-hypertensive agent and for treating hypertension.
Highlights
Cardiovascular diseases (CVD), which are among the most common adult diseases, are leading causes of death among Organisation for Economic Co-operation and Development (OECD) member states. Jimsheena and Gowda (2011) reported that CVDs was caused by consumers’ reduced physical activity and increasing consumption of high-energy foods
Thirteen fruits and 15 seeds including legumes, nuts, and cereals were combined in pairs; pearhemp seed-pumpkin seed juice (3-mixed juice) displayed the highest angiotensin I-converting enzyme (ACE) inhibition resulting from synergistic interactions
By examining the synergistic anti-hypertensive effect of fruit–seed mixed juice produced by adding seeds to fruits, which are often consumed as beverages, this study aims to develop a fruit– seed mixed juice beverage to improve cardiovascular health and function
Summary
Cardiovascular diseases (CVD), which are among the most common adult diseases, are leading causes of death among Organisation for Economic Co-operation and Development (OECD) member states. Jimsheena and Gowda (2011) reported that CVDs was caused by consumers’ reduced physical activity and increasing consumption of high-energy foods. Cardiovascular diseases (CVD), which are among the most common adult diseases, are leading causes of death among Organisation for Economic Co-operation and Development (OECD) member states. Jimsheena and Gowda (2011) reported that CVDs was caused by consumers’ reduced physical activity and increasing consumption of high-energy foods. Among other ordinary CVDs, hypertension can cause metabolic disorders including obesity, prediabetes, and atherosclerosis (Tavares et al, 2012). Increased blood pressure (BP) can be controlled by antihypertensive drugs. Synthetic drugs have side effects such as cough, skin rash, or angioneurotic edema (Riccioni et al, 2009; Wijesekara and Kim, 2010). As the side effects of many different synthetic drugs have been determined and published widely, research on the bioactive function of natural foods has recently gained attention
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