Abstract
The carcinogenic effect of dimethylnitrosamine (DMN) injected subcutaneously in Syrian golden hamsters as well as the synergistic effect of intratracheal instillations of ferric oxide were studied. DMN alone induced cavernous hemangiomas, hemangioendotheliomas, hemangioendotheliosarcomas, as well as one hepatoma of the liver and one papilloma of the forestomach, but no tumors of the respiratory system. When ferric oxide was given in addition to DMN, liver tumors of vascular and biliary origin were seen, in addition to tumors of the nasal cavity, neuroepithelial tumors and one adenoma. It was concluded that subcutaneously injected DMN is a powerful hepatic carcinogen for the Syrian golden hamster, producing liver tumors of vascular, bile duct as well as liver cell origin. The lack of tumorigenic effect in the respiratory system was considered to be due to the lack of metabolism of DMN in the lung.
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