Synergistic Cu/Pd Catalysis for Enantioselective Allylation of Ketimine Esters: The Direct Synthesis of α‐Substituted α‐Amino Acids and 2H‐Pyrrols

Abstract

AbstractAn efficient synergistic Cu/Pd catalyzed enantioselective α‐allylation of acyclic ketimine esters has been reported, which provides an entry to nonproteinogenic α‐allyl α‐amino acids in high yield, exclusive regioselectivity, and excellent enantioselectivity. Moreover, the more challenging cyclic ketimine ester could also be employed as a nucleophile for the construction of 3,4‐dihydro‐2H‐pyrrole derivatives bearing a quaternary stereogenic center using the same catalytic system.magnified image