Synergistic cancer risk assessment from PM1 bound metals and PAHs in the Indo-Gangetic Region

Abstract

The atmospheric particulate matter (PM) contains a significant amount of human carcinogens such as metals and Polycyclic Aromatic Hydrocarbons (PAHs). Previous studies have clearly shown that these carcinogens pose serious health issues due to the inhalation of particulate matter. Since the synergistic roles of these carcinogens are rarely considered, these studies frequently underestimate the health risk to humans. The current research aims to bridge this information gap by estimating the synergistic carcinogenic risk assessment owing to PM1 bound metals and PAHs across the densely populated Indo-Gangetic Plain (IGP). The carcinogenic risk assessment was conducted in accordance with the USEPA guidelines on these various PM1 bound components. The Incremental Lifetime Cancer Risk (ILCR) due to heavy metals, such as Lead (Pb) and Chromium (Cr), was found beyond the acceptable limit (> 10−4). The risk due to PM1 bound USEPA PAHs was also significantly higher (> 10−5). This study further estimated the potential toxicity from broad domain of environmental PAHs present in ambient air by considering relevant estimation factors from existing literature. The projected risk from these diverse environmental PAHs was of the order 10−4. Further, source identification of PAHs based on diagnostic isomer ratios revealed that diesel exhaust, biomass burning, and coal combustion are the dominant PAHs sources. Moreover, the exposure to these pollutants is higher in winter and post-monsoon periods. Overall, the synergistic carcinogenic risk found from metals and PAHs was of the order 10−3. In a nutshell, inhalation of PM1 bound heavy metals and PAHs at IGP can result in the development of 1000 cancer cases per million population, which is the highest value compared to other parts of the world. The present study demands immediate policy interventions not only for the reduction of particulate pollution, but also for the reduction of carcinogenic species from the ambient air in order to improve human health.