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Abstract
Meeting abstracts NKTR-214 is an immunotherapeutic drug that exerts its biological activity by binding and activating the interleukin-2 (IL-2) receptor beta subunit (IL-2Rb), thereby causing expansion of memory effector T cells in the tumor. NKTR-214 consists of 4-6 releasable polyethylene glycol (
Highlights
NKTR-214 is an immunotherapeutic drug that exerts its biological activity by binding and activating the interleukin-2 (IL-2) receptor beta subunit (IL-2Rb), thereby causing expansion of memory effector T cells in the tumor
Synergistic antitumor activity of the CD122-biased immunostimulatory cytokine NKTR-214 when combined with anti-PD-1 in murine tumor models
Efficacy was determined based on tumor growth inhibition relative to vehicle (TGI), long-term tumor growth delay measured by time to reach 4x initial tumor volume (Tumor Volume Quadrupling Time, TVQT), and number of long term tumor-free animals
Summary
Addepalli Murali, John L Langowski2*, Pena Rhoneil, Priyam Jha, Deborah H Charych, Stephen K Doberstein, Ute Hoch. From 30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015) National Harbor, MD, USA. From 30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015) National Harbor, MD, USA. 4-8 November 2015
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