Synergistic antidepressant effect of Schisandra lignans and Schisandra polysaccharides

Abstract

The CUMS（Chronic unpredictable mild stress） method was used to establish a depression model，and the combination of schisandra lignans and schisandra polysaccharides was used for drug treatment, and its effect on the depressive behavior of mice was observed through behavioral indicators, and then the synergistic anti-inflammatory effects of schisandra lignans and schisandra polysaccharides were explored. The study found that the food intake of the CUMS-induced model mice decreased significantly after depression, and major symptoms such as depression, anxiety, loss of libido, and weight loss appeared. After 28 days of administration, the depression symptoms of the positive control group, Schisandra lignan group, Schisandra polysaccharide group, Schisandra lignan and polysaccharide group gradually improved, while the model group showed obvious depression. Schisandra lignans and Schisandra polysaccharides have synergistic antidepressant effects.