Synergistic and Safe Antidiabetic Effect of Polyherbal Formulation: Comprehensive Overview

Abstract

Diabetes is a metabolic disorder and enhances the glucose level in the blood. The synthetic antidiabetic agents are limited to the management of diabetes due to its adverse effects. The herbal medicines are the alternative and better option for the management of diabetes. Mostly Ayurvedic formulations are polyherbal formulation and impart chief role for the treatment of diabetes. The polyherbal formulation illustrates the combination of two or more herbs in formulation. The herbal components in the polyherbal formulation interacts leading to synergistic antidiabetic effect compared to the individual herb. Frequent available reports show evidence of synergistic effect of polyherbal drugs and their mechanism of action. But due to scanty availability of these reports in electronic libraries the researcher has to search the hard copies which leads to wastage of effort and time. To overcome these lacuna, this article was undertaken to scientifically review the in vitro and in vivo research studies on antidiabetic polyherbal formulations Further, the data presented in this review exploration of synergistic mechanisms of the antidiabetic polyherbal formulation will not only assist researchers to discover new phytomedicines or drug combinations but also support to avoid the possible negative synergy. Additionally, it would assist in clinical research for carrying out clinical trials to assess the efficacy of these herbal combinations and guide in understanding their synergistic mechanisms.
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