Abstract
Journal of Unexplored Medical Data is an open access journal, which considers well-conducted medical science studies, including clinical trials, pilot studies, research reports, original articles, reviews and short communications in the field of medical science.
Highlights
In the case of the resistance of acute promyelocytic leukemia to all-trans retinoic acid (ATRA) induction treatment, arsenic trioxide (ATO) has proven to be an effective second line therapy[1]
Considering that the cells of promyelocytic leukemia are characterized by an increased level of oxidative stress[5,6], and may show increased sensitivity to cytotoxic effects of prooxidants, it is reasonable to seek novel therapies based on free radical mechanisms
PTL significantly increased the number of dead HL-60 cells in comparison to the control [Figure 1A]
Summary
In the case of the resistance of acute promyelocytic leukemia to all-trans retinoic acid (ATRA) induction treatment, arsenic trioxide (ATO) has proven to be an effective second line therapy[1]. One such potential compound of plant origin, whose mechanism of antineoplastic activity is the induction of oxidative stress is parthenolide (PTL)[7]. This compound belongs to the group of sesquiterpene lactones
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