Abstract
The joint oral Administration of piperonyl butoxide (1:5) increased the toxicity of both Bayer 21/199 ( O -(3-chloro-4-methylumbelliferone) O,O -diethyl phosphorothioate) and its corresponding phosphate to mice four- to six-fold. This increase in toxicity was also found when synergist and toxicant were administered by different routes. Piperonyl butoxide increased the in vivo but not the in vitro inhibition of mouse brain cholinesterase by 21/199 or its phosphate. Preliminary studies with p32 labeled 21/199 demonstrated that the joint administration of piperonyl butoxide inhibited its metabolism to more polar metabolites.
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