Abstract
The interaction of estradiol (E) and testosterone (T) in the regulation of growth and function of the magnum from the immature chicken oviduct (11 weeks of age) was investigated following periodic injections of E and T singly, or combinations of the two hormones. T, in contrast to E, induced only limited increases in magnum weight, DNA, RNA and protein; it did not induce formation and differentiation of tubular gland cells and, consequently, no synthesis of egg white protein was observed. T, when administered with E, synergized magnum growth. A low or median level of T in combination with E stimulated both hyperplasia (increases in total DNA) and cellular hypertrophy (increases in dry matter/DNA, RNA/DNA and protein/DNA ratios). A high level of T in combination with E caused cellular hypertrophy only. Immunological and electrophoretic techniques revealed that T, in synergism with E, induced a marked increase in total ovalbumin and conalbumin in the magnum as well as in the content of these egg white prote...
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