Abstract
This communication is called forth by the repetition of statements to the effect that no satisfactory evidence has been brought forward to show that the synergism. of magnesium sulphate and morphine occurs in animals or in man.1 To my knowledge, the following definition of synergism has not been challenged:2 By synergism (a Greek derivative meaning working together with) is meant the reciprocal augmentation of the action of one drug by that of another. This reciprocal augmentation of the action of one anesthetic agent by that of another induces the state which has come to be known as synergistic anesthesia when accompanied by unconsciousness, and synergistic analgesia when the subject is conscious. The effect of the synergistic action of drugs goes beyond a simple summation of similar pharmacological actions, either in prolonged or deepened action, or both. For example: morphine and magnesium sulphate have a prolonged effect; whereas with
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