Abstract
Synergism Between Nigella sativa Seeds Extract and Synthetic Antibiotics Against Mec A Gene Positive Human Strains of Staphylococcus aureus
Highlights
The anti-Methicillin-Resistant Staphylococcus aureus (MRSA) activity was reduced when methanolic extracts of Nigella sativa seeds were used in combination with the pain reliever and the fever reducer paracetamol
It has been observed that the anti-staphylococcal activity of Nigella sativa led to changes in bacterial cell morphology indicating that the cell wall of Gram-positive bacteria as likely a target of action
This study provides new insights about synergistic antimicrobial and Nigella sativa crude extract activities against multidrug resistant (MDR)
Summary
Methicillin-Resistant Staphylococcus aureus (MRSA) infections have become a global health problem in hospital setup causing simple skin infections to life-threatening infections[2,3]. Staphylococcus aureus (S. aureus) is a Gram positive bacterium and is known to develop quick resistance to antimicrobial agents. The attainment of Mec A gene by horizontal transmission by conjugation was the main cause of antibiotic resistance in S. aureus[10]. Synergistic combinations of various antimicrobial agents have been introduced as extra successful strategies to combat multidrug resistant (MDR) infections. This study was undertaken to evaluate MDR profiling of Staphylococcus aureus strains isolated from clinical specimens of two public hospitals of twin Pakistani cities as well as to explore in vitro antibacterial potential of Nigella sativa L. (black cumin or black seeds) extract against Mec A gene positive Staphylococcus aureus strains This study was undertaken to evaluate MDR profiling of Staphylococcus aureus strains isolated from clinical specimens of two public hospitals of twin Pakistani cities as well as to explore in vitro antibacterial potential of Nigella sativa L. (black cumin or black seeds) extract against Mec A gene positive Staphylococcus aureus strains
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