Synergism between maternal and offspring high fat diet feeding in the non-human primate neuroactive metabolome

Abstract

The microbiome produces small molecules, including neuroactive metabolites crucial for normal lifelong behavior. In a non-human primate (NHP) model, offspring exposed to maternal high fat diet (mHFD) display physiological changes compared to offspring exposed to maternal control diet (mCTR). To investigate the relationship between maternal diet and offspring post-weaning diet, we hypothesized that mHFD exposure plus a post-weaning high fat diet (HFD) will produce a persistently altered gut metabolome profile in vivo compared to mCTR exposure.