Abstract
The cooperation of ligustrazine (LI) and borneol was proved to be much better than each of them in treating cerebral ischemia. However, the mechanism of their synergic therapy is unclear till now. Moreover, whether their cooperation brought different degrees of protection among different brain regions was also unclear. In the present study, the effects of LI, borneol, and their mixture were observed in global cerebral ischemia-reperfusion (GCIR) injury by detecting microcirculation, expressions of caspase-3 and p53, levels of IL-1β, IL-6, and TNF-α, and contents of SOD, GSH-Px, and MDA in cortex, hippocampus, hypothalamus, and striatum, respectively. Furthermore, Nissl bodies were scored also. Monotherapy of LI or borneol showed obvious improvements in the four regions, specially in cortex and hippocampus. Interestingly, the cooperation of LI and borneol brought some new improvements, specially in hypothalamus and striatum. Thus, the synergic effect of the two drugs showed region-specificity in GCIR injury except the expressions of caspase-3 and p53.
Highlights
Cerebrovascular disorder comprises a group of neurological diseases, in which ischemic stroke is one of the most severe cerebropathies and considerably impairs patient’s life quality
Microcirculation disorders are induced by cerebral ischemia, while the onset of reperfusion after cerebral ischemia produces much larger damage because there is a burst of free radical generation in that period [2, 3]
Cerebral ischemia-reperfusion attack brings a larger damage than simplex ischemia because the former produces a large number of oxygen-free radicals, which always leads to breakdown of cytomembrane
Summary
Cerebrovascular disorder comprises a group of neurological diseases, in which ischemic stroke is one of the most severe cerebropathies and considerably impairs patient’s life quality. Ischemic stroke accounts for 88% of all strokes and is characterized by rapidly developing clinical signs of disturbance in the cerebral function [1]. Microcirculation disorders are induced by cerebral ischemia, while the onset of reperfusion after cerebral ischemia produces much larger damage because there is a burst of free radical generation in that period [2, 3]. Ischemia/reperfusion injury (IRI) is more common in cerebrovascular disorders than simple ischemia because of thrombolytic therapies. (Chung Xiong), and is widely used in patients with cerebral ischemia in clinic [4, 5].
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