Abstract
Purpose: The ultimate aim of this study is to observe the effect of Green tea as a co-antioxidant in PAGAT gel dosimeter and evaluate the appropriate light source for scanning the PAGAT and NIPAM polymer gel. Methods: Both PAGAT (Poly Acrylamide Gelatin Tetrakis hydroxyl phosphonium chloride) and NIPAM (N-Isopropyl acrylamide) gel were prepared in normoxic condition. The green tea extract (GTE) was prepared and tested only on PAGAT. Co-60 teletherapy machine has been used for irradiation purpose, and the gel samples were scanned using UV-Visible spectrophotometer. Water equivalency of the gel has been tested in terms of their electron density, effective atomic number and Ratio of oxygen and hydrogen (O/H). We have used NIST XCOM database to test the water equivalency. Results: In this study we found that the GTE added to the gel do not respond to the given doses. By adding sugar we can enhance the sensitivity of the gel. Further investigations are required to use Green tea as a co antioxidant concentration of THPC (Tetrakis hydroxymethyl phosphonium chloride). The optimal wavelength with different region for scanning the PAGAT is 450 to 480 nm (Blue region), for NIPAM it is 540 nm and 570 nm (Green and yellow region). The PAGAT and NIPAM showed better sensitivity at 510 nm. Both gels have their effective atomic number closer to water (NIPAM-7.2, PAGAT-7.379). Conclusion: As per our results, we concluded that GTE alone is not an effective co-antioxidant for polymer gels. When the GTE is combined with sugar and THPC, it protects the gel from pre-polymerization. This study strongly suggests that the blue light is an optimal source for scanning the PAGAT and green to yellow light for NIPAM gel. Though both gels were considered as water equivalent, the PAGAT is equivalent to water and the temporal stability of this gel is higher than NIPAM.
Highlights
Verification of the 3D dose distribution is a part of patient specific quality assurance work in radiotherapy
This study strongly suggests that the blue light is an optimal source for scanning the PAGAT and green to yellow light for NIPAM gel
The preparation procedure of NIPAM has been done as per the report by Senden et al.[6]. Both the gels were irradiated by Co-60 source and the dose information was extracted by UV-Visible spectrophotometer. 2.1 Preparation of green tea extract (GTE) Dried green tea leaves were commercially purchased. 1g of leaves was soaked in 50 ml of water (Millipore) for 4 hours
Summary
Verification of the 3D dose distribution is a part of patient specific quality assurance work in radiotherapy. Polymer gel dosimeter offers reliable 3D dose verification. Since the gel is equivalent to water and it is sensitive to radiation, it can be used both as a phantom and radiation detector as well. It is known fact among the researchers that polymer gel dosimeter has initiated a new realm in the radiotherapy field due to its tissue equivalency, angular independency, good spatial resolution and the availability of various readout techniques such as optical-computed tomography (CT), x-ray-CT, magnetic resonance imaging (MRI), ultrasound CT, and vibrational spectroscopy. The gel has its own disadvantages such as toxic chemical ingredients, time
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
