Abstract
Background: Ciprofloxacin (CIP), an important broad-spectrum fluoroquinolone antibiotic, was often used as a template molecule for the preparation of imprinted materials. In this study, methacrylic acid and 2-vinylpyridine were employed for the first time as dual functional monomers for synthesizing ciprofloxacin imprinted polymers. Methods: The chemical and physicochemical properties of synthesized polymers were characterized using Fourier transform-infrared spectroscopy, thermogravimetric analysis-differential scanning calorimetry, scanning electron microscopy, and nitrogen adsorption-desorption isotherm. The adsorption properties of ciprofloxacin onto synthesized polymers were determined by batch experiments. The extraction performances were studied using the solid phase extraction and HPLC-UV method. Results: The molecularly imprinted polymer synthesized with dual functional monomers showed a higher adsorption capacity and selectivity toward the template molecule. The adsorbed amounts of ciprofloxacin onto the imprinted and non-imprinted polymer were 2.40 and 1.45 mg g−1, respectively. Furthermore, the imprinted polymers were employed as a selective adsorbent for the solid phase extraction of ciprofloxacin in aqueous solutions with the recovery of 105% and relative standard deviation of 7.9%. This work provides an alternative approach for designing a new adsorbent with high adsorption capacity and good extraction performance for highly polar template molecules.
Highlights
Ciprofloxacin (CIP) is an important antibiotic belonging to the class of fluoroquinolones.It is a broad spectrum of an antibacterial agent widely applied to treat various infectious diseases in animals and humans [1]
These results indicated that the highly polar solvent was suitable for preparing CIP-Molecularly imprinted polymers (MIP) and the weakly polar solvent unfavored the interaction between the monomer and the template molecule
Higher extraction recoveries (63–105%) were observed when dual functional monomers were used to prepare the imprinted polymer in which the MIP7, synthesized with the methacrylic acid (MAA)/2-VP molar ratios of 0.66:0.33, showed the highest recovery (105%). These results indicated that the extraction performance of MIP was considerably improved by combining MAA and 2-VP as dual functional monomers
Summary
Ciprofloxacin (CIP) is an important antibiotic belonging to the class of fluoroquinolones. It is a broad spectrum of an antibacterial agent widely applied to treat various infectious diseases in animals and humans [1]. Ciprofloxacin (CIP), an important broad-spectrum fluoroquinolone antibiotic, was often used as a template molecule for the preparation of imprinted materials. Methacrylic acid and 2-vinylpyridine were employed for the first time as dual functional monomers for synthesizing ciprofloxacin imprinted polymers. Results: The molecularly imprinted polymer synthesized with dual functional monomers showed a higher adsorption capacity and selectivity toward the template molecule. The imprinted polymers were employed as a selective adsorbent for the solid phase extraction of ciprofloxacin in aqueous solutions with the recovery of 105% and relative standard deviation of 7.9%. This work provides an alternative approach for designing a new adsorbent with high adsorption capacity and good extraction performance for highly polar template molecules
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