Synephrine and phenylephrine act as α‐amylase, α‐glycosidase, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase enzymes inhibitors

Abstract

In this paper, synephrine and phenylephrine compounds showed excellent inhibitory effects against human carbonic anhydrase (hCA) isoforms I and II, α-amylase, α-glycosidase, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). Synephrine and phenylephrine had Ki values of 199.02±16.01 and 65.01±5.00μM against hCA I and 336.02±74.01 and 92.04 ± 18.03μM against hCA II, respectively. On the other hand, their Ki values were found to be 169.10 ± 80.03 and 88.03 ± 5.01nM against AChE and 177.06 ± 6.01 and 78.03 ± 3.05nM against BChE, respectively. α-Amylase and α-glycosidase enzymes were easily inhibited by these compounds. α-Glycosidase inhibitors, generally defined to as starch blockers, are anti-diabetic drugs that help to decrease post comestible blood glucose levels.