Syndrome similar to Familial Hypocalciuric Hypercalcemia (FHH) produced in mice deleted of the gene encoding transient receptor potential canonical channel 1 (TRPC1)

Abstract

We recently found that global deletion of TRPC1 produces phenotypes similar to FHH [1]. These TRPC1 null mice have mildly elevated serum Ca in both fasted and unfasted conditions from 3.5 through 21.5 months of age, and inappropriately elevated parathyroid hormone (PTH) levels.