SYNDROME OF AUTONOMIC DYSFUNCTION IN CHILDREN OF YOUNG SCHOOL AGE: RISK FACTORS AND STRUCTURAL AND FUNCTIONAL STATE OF ERYTHROCYTE MEMBRANES

Abstract

Aim. To study the anamnesis and physical and chemical characteristics of erythrocyte membranes in schoolchildren aged 7-11 years to determine the risk of developing autonomic dysfunction syndrome in a particular child. Materials and methods. Clinical, anamnestic and laboratory examination of schoolchildren aged 7-11 years with the syndrome of autonomic dysfunction and practically healthy children was carried out. The physical and chemical properties of erythrocyte membranes were studied by fluorescence spectroscopy. Results. In children with autonomic dysfunction syndrome, the method of fluorescence spectroscopy revealed structural transformations and changes in the functions of erythrocyte membranes of a destabilizing nature. Significant biophysical risk factors for the development of autonomic dysfunction syndrome in children in children of 7-11 years old turned out to be: low calcium-accumulating capacity of membranes, high rates of membrane-bound water and fluidity of the surface layers of the membrane, as well as an increased coefficient of asymmetry of the fluidity of the lipid bilayer. Conclusion. Identification of significant anamnestic and biophysical (at the membrane level) risk factors in a particular child is necessary to include the child in the risk group for psychosomatic diseases for dynamic monitoring and timely implementation of preventive measures.