Abstract
Syndecans are heparin sulfate protoglycans that are associated with cell surface and extra cellular matrix. Invertebrates have one syndecan core protein but in mammals there are four syndecan proteins. Each protein has three major domains; ectodomain, transmembrane domain and cytoplasmic domain. Cytoplasmic domain are the most conserved and serve to regulate the signalling of growth factors. They have also been shown to be involved in cell signalling through interaction with integrins and tyrosine kinase receptors. These cell surface proteins are thought to play an important role in cell matrix and cell - cell adhesion, migration and proliferation. So, this review summarized the structure, properties and functions of various syndecan molecules in both health and disease.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
