Abstract
Cell-matrix interactions in morphogenesis The important role of the extraceUular matrix (ECM) in regulation of organ morphogenesis has been recognized for several decades (Grobstein, 1967; Bernfield et al., 1972; Lash and Vasan, 1978; Hay, 1981; Toole, 1981). When the main categories of matrix constituents, the collagens, other glycoproteins and proteoglycans with their different glycosaminoglycan side chains had been identified, their roles were studied in the development of different embryonic organs. Experiments where their accumulation was perturbed indicated developmental significance for molecules from all different categories, and metabolic labelling studies suggested that they were developmentally regulated (KaUman and Grobstein, 1966; Bernfield et al., 1972; Hetem et al., 1985). Subsequently, the localization of individual molecules by specific antibodies and immunohistology indicated that the distribution patterns of different matrix molecules correlated with morphogenetic changes, suggesting again developmental roles for the ECM
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