Abstract
In the quest for finding the ideal synchrotron-radiation-induced imaging method for the investigation of trace element distributions in human bone samples, experiments were performed using both a scanning confocal synchrotron radiation micro X-ray fluorescence (SR-µXRF) (FLUO beamline at ANKA) setup and a full-field color X-ray camera (BAMline at BESSY-II) setup. As zinc is a trace element of special interest in bone, the setups were optimized for its detection. The setups were compared with respect to count rate, required measurement time and spatial resolution. It was demonstrated that the ideal method depends on the element of interest. Although for Ca (a major constituent of the bone with a low energy of 3.69 keV for its Kα XRF line) the color X-ray camera provided a higher resolution in the plane, for Zn (a trace element in bone) only the confocal SR-µXRF setup was able to sufficiently image the distribution.
Highlights
Synchrotron radiation micro X-ray fluorescence (SR-mXRF) has proven to be a forceful method to perform imaging of trace elements in various materials (Janssens et al, 2010; West et al, 2015)
SR-mXRF imaging techniques exist in full-field and in scanning mode
Confocal SR-mXRF measurements were performed at the FLUO beamline at ANKA (KIT, Karlsruhe, Germany)
Summary
Synchrotron radiation micro X-ray fluorescence (SR-mXRF) has proven to be a forceful method to perform imaging of trace elements in various materials (Janssens et al, 2010; West et al, 2015). Whereas confocal SR-mXRF (a scanning-mode technique) for measurements of trace elements distributions in bone and cartilage has been successfully used before (Roschger et al, 2013, 2010; Pemmer et al, 2013, 2011; Smolek et al, 2012; Zoeger et al, 2008), the question remained whether or not a full-field technique would decrease measurement time and improve resolution. All this makes the analysis of Zn distributions in bone very intriguing. Both of the setups were optimized to measure Zn
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