Abstract
Breast cancer rarely metastasizes to the uterus. Here, we report two breast cancer patients with synchronous metastases to the uterus. Case 1 highlights a 46-year-old female with invasive ductal carcinoma who presented with a breast mass and was found to have uterine enlargement on positron emission tomography (PET) scan. Biopsy revealed a metastatic 4 mm focus of breast cancer in the background of endometrial hyperplasia. Case 2 reports a 62-year-old postmenopausal female diagnosed with lobular carcinoma of the breast following an abnormal screening mammogram. A routine pap smear necessitated further workup, revealing simultaneous endometrial and cervical metastasis. Both patients did not have any gynecologic symptoms and presented a diagnostic challenge.
Highlights
BackgroundBreast cancer is the most common cancer worldwide and accounts for 29% of all cancers in women
Case 1 highlights a 46-year-old female with invasive ductal carcinoma who presented with a breast mass and was found to have uterine enlargement on positron emission tomography (PET) scan
The patient was discussed during a multidisciplinary conference, and the consensus was that the patient has a bilateral breast lobular carcinoma with metastases of the right breast carcinoma to the right axillary lymph nodes as well as the endometrium
Summary
Breast cancer is the most common cancer worldwide and accounts for 29% of all cancers in women. Given the enlarged uterus of 5.6 x 4.0 cm with an endometrium of 5 mm, a gynecology service was consulted and an endometrial biopsy was obtained, demonstrating metastatic lobular carcinoma, involving the endocervix. The patient was discussed during a multidisciplinary conference, and the consensus was that the patient has a bilateral breast lobular carcinoma with metastases of the right breast carcinoma to the right axillary lymph nodes as well as the endometrium She was offered hormonal and systemic chemotherapy with or without hysterectomy. The patient declined any further treatment and was lost to follow-up
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