Abstract
Malignant transformation of a benign cystic teratoma of the ovary is only rarely seen. A review of the English literature revealed no reports of a malignant melanoma developing from concurrent primary endometrial carcinoma and ovarian cystic teratoma. We report herein a 54-year-old nulliparous woman who underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy for a pelvic mass and was diagnosed by histopathological examination to have a malignant melanoma developing from concurrent primary endometrial carcinoma and ovarian cystic teratoma. No foci of primary malignant melanoma except for the ovary were found upon clinical examination. The patient received postoperative interferon alpha 2B and radiotherapy. She was still asymptomatic at 12 months of follow-up.
Highlights
Malignant transformation of a mature teratoma is quite rare
Squamous cell transformation accounts for 90-97% of all malignant transformations of mature teratomas
A total of 37 cases have been reported so far in the English literature [6,7,8,9,10,11,12]. This case is the first and only case in which a primary malignant melanoma developed from a mature teratoma of ovary while there was a concurrent primary endometrial carcinoma in uterus
Summary
Malignant transformation of a mature teratoma is quite rare. Squamous cell transformation accounts for 90-97% of all malignant transformations of mature teratomas. Primary ovarian malignant melanoma was first reported in 1901 [5]. A total of 37 cases have been reported so far in the English literature [6,7,8,9,10,11,12]. This case is the first and only case in which a primary malignant melanoma developed from a mature teratoma of ovary while there was a concurrent primary endometrial carcinoma in uterus. Postsurgical histopathological examinations reveal concurrent primary ovarian and primary endometrial carcinoma at a rate of 5-15%, while the same rate climbs up to 30-40% in postmortem examinations [13,14]
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