Synchronous Primary Endometrial and Ovarian Cancers: A Critical Update

Georgios Androutsopoulos,Georgios Decavalas

doi:10.15344/2394-4986/2015/106

Georgios Androutsopoulos, Georgios Decavalas

Open Access

https://doi.org/10.15344/2394-4986/2015/106

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Abstract

Synchronous primary cancers are relatively uncommon in general population. Only 0.5-1.7% of women with gynecological malignancies, have synchronous primary cancers of the female genital tract. In those patients, the most common combination is synchronous primary endometrial and ovarian cancers.

Highlights

Patients with synchronous primary endometrial and ovarian cancers have distinct clinical characteristics including: young age, obesity, premenopausal status and nulliparity [9]
It is possible that those patients have a more fragile genome and prior genetic damage may predispose them to the development of synchronous primary cancers [16,19,20,21,22,23] Especially in patients with Lynch syndrome, there is a predisposition to multiple synchronous primary cancers [24]
Pelvic and para-aortic lymphadenectomy is essential for surgical staging in patients with synchronous primary endometrial and ovarian cancers [1,2,31,32]

Summary

Introduction

Patients with synchronous primary endometrial and ovarian cancers have distinct clinical characteristics including: young age, obesity, premenopausal status and nulliparity [9]. The most common presenting symptoms and signs in patients with synchronous primary endometrial and ovarian cancers, are: abnormal uterine bleeding (46%), abdominal/pelvic pain (17%) and abdominal/ pelvic mass (13%) [1,2,9,11,13,15,16,25]. Synchronous primary endometrial and ovarian cancers may have similar or different histologic appearance [6,10,14]. The treatment of choice for most patients with synchronous primary endometrial and ovarian cancers, is systematic surgical staging [1-4 ,6,11,12,14,15,28-30].

Results

Conclusion