Abstract
Metastasis to the glans penis is a rare phenomenon and usually occurs in a late stage of disease. A 68-year-old man was referred to our clinic because of two indurated lesions of the glans penis and minor lower urinary tract symptoms. Digital rectal examination revealed a hard nodular prostate, and serum prostate-specific antigen (sPSA) level was 13.3 ng/mL. Biopsies of the penile lesions and transrectal ultrasound-guided prostate biopsies were taken. Immunohistochemical staining of formalin-fixed paraffin-embedded tissue exposed a synchronous penile metastasis from a high-grade adenocarcinoma of the prostate. Except a pathologically enlarged lymph node detected with MRI there was no suspicion on other metastases. Currently this patient is being treated with a Gonadoreline (GnRH) antagonist. Nevertheless, the prognosis will be poor.
Highlights
Prostate cancer is the most frequent solid malignancy diagnosed in the Western male population, and the incidence is still rising [1]
This paper deals with a 68-year old patient diagnosed with synchronous penile metastases from a high-grade prostate carcinoma, without distant metastasis, a case never been described in literature before
Prostate cancer is the most common malignancy in the male population, and despite various treatment options it progresses to a metastatic stage disease in many patients
Summary
Prostate cancer is the most frequent solid malignancy diagnosed in the Western male population, and the incidence is still rising [1]. An estimated 8% of all prostate cancers is diagnosed in an advanced stage of disease [2]. Metastases to the penis are a rare phenomenon, and the prognosis is usually very poor [3]. This paper deals with a 68-year old patient diagnosed with synchronous penile metastases from a high-grade prostate carcinoma, without distant metastasis, a case never been described in literature before
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