Abstract
Objective To study the phase coherence mode of multi-channel local field potentials (LFPs) of rats cortex under waking, propofol anesthetized and recovery of righting reflex situations and to apply it to estimate the anesthetic degree. Methods Five male Sprague-Dawley rats were selected and 16-channel micro-electrode matrix were implanted in the prefrontal cortex of the rats. Ten days later, 16-channel electric signals were recorded from waking rats using Cerebus 128 Data Acquisition System. Then the rats were anesthetized with propofol intravenously through the tail vein, with the induction dose of propofol of 10 mg/kg and anesthesia maintenance dose of put and the rat regained consciousness, 16-channel electric signals from anaesthetic rats were recorded. After preprocessing, phase coherence of LFPs was calculated among the data from these three situations. Phase coherences were calculated in each window between each signal channel LFP and reference channel LFP with 200-ms multitaper window sliding from the beginning. Time-varying phase coherence dynamic distribution was available between each channel LFP and reference channel LFP with 25-ms overlapping. Results The results shows that the phase coherence average number in waking situation is less than the number in anesthesia (P<0.05); the phase coherence average number in recovery situation is less than that of anesthesia (P<0.05), it is larger than the number in anesthetic situation on the contrary (P<0.05). Conclusion The result indicates that the no synchronization of the LFPs during the waking-up time was found. High synchronization of the LFPs during the anesthetic period was found, while the degree of synchronization of the LFPs during the recovery time was between that of waking-up time period and anesthetic period. It can be applied to identify anesthetic degree of propofol. Key words: Prefrontal cortex of rats; Anesthetic degree of propofol; Local field potentials; Synchronization
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