Synchronous Occurrence of Juvenile Ossifying Fibroma of The Mandible And Maxilla: Case Report

Abstract

Juvenile ossifying fibroma (JOF) is an uncommon, benign, bone-forming neoplasm distinguished from other fibro-osseous lesions primarily by its age of onset, clinical presentation, aggressive behavior, and high tendency to recur. An atypical case is presented. Man, 26, manifested synchronous JOF lesions, with one in the left mandible measuring 10 cm and one in the left maxilla measuring 5 cm with a multilocular radiolucent radiographic appearance. The lesions were treated by hemimandibulectomy and curettage, respectively. Microscopically, the lesions were composed of cell-rich fibrous stroma associated with bony trabeculae exhibiting different degrees of mineralization and spherical ossicles showing basophilic centers and peripheral eosinophilia. Synchronous presentation of this neoplasm in the maxilla and mandible is rare. JOF can share clinicopathological features with other fibro-osseous lesions and bone neoplasms. Clinicoradiologic and histopathological criteria for JOF are discussed, along with suggestions to guide early diagnosis, suggest appropriate treatment, and, especially, provide long-term follow-up of patients.