Synchronous Lipoma and Epithelial Dysplasia on Both Sides of Tongue: Report of a Case

Abstract

Synchronous lesions (SLs) are primary diseases that arise in the same patient with a maximum interval of 6 months. We report the case of a 69-year-old man, presenting with an asymptomatic yellowish nodular lesion of resilient consistency on the right side of the border of the tongue; an asymptomatic polypoid lesion with ulcerated areas was observed on the left side. Provisional diagnoses of lipoma and epidermoid carcinoma were established, for which excisional and incisional biopsies were performed, respectively. Pathologic analysis of the first lesion revealed proliferation of mature adipocytes in a lobular arrangement, and the second lesion showed deep and irregular hyperplasia of oral squamous epithelium with focal areas of atypia. The diagnosis was lipoma and mild epithelial dysplasia with pseudoepitheliomatous hyperplasia. A discussion on the relevance of SL of the oral mucosa will be provided, particularly the rarity of unrelated lesions with distinct biologic nature.