Synchronous HPV-Positive Squamous Cell Carcinoma of the Bilateral Base of the Tongue

Abstract

Although there have been several reports of synchronous Human Papillomavirus (HPV)-associated tonsillar carcinoma, no reports have shown synchronous HPV-associated Base of The Tongue (BOT) carcinoma. Here we discuss a case of synchronous HPV-associated BOT carcinoma and review the literature concerning HPV-associated second primary tumors. We report the case of a 59-year-old man with synchronous HPV-positive Squamous Cell Carcinoma (SCC) of the bilateral BOT. Both BOT SCCs were positive for HPV16. The patient received concomitant cisplatin radiotherapy, and remains disease-free at 18 months post-treatment.