Abstract
Calcium (Ca 2+) signals were monitored in individual neutrophils using ratio imaging of fura-2. In contrast to N-formyl-L-leucyl-L-phenylaianine (f-met-leu-phe), which produced grossly asynchronous Ca 2+ signals with delays in response (up to 60 s), leukotriene B 4 (LTB 4) provoked synchronous and immediate elevations in cytosolic free Ca 2+. Some individual neutrophils which responded immediately to LTB 4, subsequently displayed delayed Ca 2+ signals in response to f-met-leu-phe. A sub-population of neutrophils failed to respond to both LTB 4 and f-met-leu-phe. The asynchrony of the Ca 2+ signalling to f-met-leu-phe is not, therefore, an obligatory property of signal transduction in neutraphils.
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