Abstract
The influence of higher nervous activity on the processes of autonomic control of the cardiovascular system and baroreflex regulation is of considerable interest, both for understanding the fundamental laws of the functioning of the human body and for developing methods for diagnostics and treatment of pathologies. The complexity of the analyzed systems limits the possibilities of research in this area and requires the development of new tools. Earlier we propose a method for studying the collective dynamics of the processes of autonomic control of blood circulation in the awake state and in different stages of sleep. The method is based on estimating a quantitative measure representing the total percentage of phase synchronization between the low-frequency oscillations in heart rate and blood pressure. Analysis of electrocardiogram and invasive blood pressure signals in apnea patients in the awake state and in different sleep stages showed a high sensitivity of the proposed measure. It is shown that in slow-wave sleep the degree of synchronization of the studied rhythms is higher than in the awake state and lower than in sleep with rapid eye movement. The results reflect the modulation of the processes of autonomic control of blood circulation by higher nervous activity and can be used for the quantitative assessment of this modulation.
Highlights
Arterial baroreflex plays an important role in the functioning of the autonomic nervous system (Subramanian et al, 2019)
The purpose of this work is to identify changes in the synchronization of processes of autonomic control of the HR and BP when analyzing the LF-components of RR-intervals and blood pressure signals in the awake state, rapid eye movement (REM) and NREM stages of sleep, as well as to study the possibility of classifying such states during the analysis of synchronization and other assessments characterizing the properties of heart rate variability (Task Force of the European Society of Cardiology [TFESC], 1996) and baroreflex sensitivity (Pagani et al, 1988)
BP signals in the awake state, NREM sleep, and REM sleep are presented in Figures 3G–I, respectively
Summary
Arterial baroreflex plays an important role in the functioning of the autonomic nervous system (Subramanian et al, 2019). It is involved in the regulation of blood pressure (BP) (Osborn et al, 2005; Albaghdadi, 2007), heart rate (HR) (Lanfranchi and Somers, 2002), and respiration (Guyenet, 2014). The baroreflex sensitivity and the activity of autonomic control processes are often used to assess the physiological state of subjects and act as the markers of the development of pathologies of various systems of the body (Lázaro et al, 2019; Hadaya and Ardell, 2020; Wessel et al, 2020)
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