Abstract
SYNOPSIS Leishmania tarentolae cells in brain‐heart infusion medium were partially synchronized in terms of DNA synthesis and cell division by a 10 hour period of inhibition in 200 μg/ml hydroxyurea at 27 C. Nuclear and kinetoplast DNA synthesis commenced immediately upon removal of hydroxyurea, and kinetoplast and nuclear division occurred after about 5 hr. The Index of Synchronization (3) varied from 33‐41%.A moderate decay of the synchronicity was noted by the 2nd cell cycle. Hydroxyurea was selectively lethal to S‐phase cells.
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